From 2004 – 2015, Dr. Lucy Peel (publishing under the surname Woodman) worked in the respiratory science laboratory of Professor Chris Brightling, contributing towards 16 research papers, all available through PubMed.
Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. Berry MA, Parker D, Neale N, Woodman L, Morgan A, Monk P, Bradding P, Wardlaw AJ, Pavord ID, Brightling CE. J Allergy Clin Immunol. 2004 Nov;114(5) :1106-9. doi: 10.1016/j.jaci.2004.08.032.
Mast cell migration to Th2 stimulated airway smooth muscle from asthmatics. Sutcliffe A, Kaur D, Page S, Woodman L, Armour CL, Baraket M, Bradding P, Hughes JM, Brightling CE. Thorax. 2006 Aug;61(8):657-62. doi: 10.1136/ thx.2005.056770. Epub 2006 Apr 6.
Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects. Woodman L, Sutcliffe A, Kaur D, Berry M, Bradding P, Pavord ID, Brightling CE. Chest. 2006 Aug;130(2):371-8.doi:10.1378/chest.130.2.371.
Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression. Kaur D, Hollins F, Woodman L, Yang W, Monk P, May R, Bradding P, Brightling CE. Allergy.2006 Sep;61(9) :1047-53. doi:10.1111/j.1398995.2006.01139.x.
Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Kaur D, Saunders R, Berger P, Siddiqui S, Woodman L, Wardlaw A, Bradding P, Brightling CE. Am J Respir Crit Care Med. 2006 Dec 1;174(11):1179-88. doi: 10.1164/rccm.200603 394OC. Epub 2006 Sep 7.
Vascular remodelling is a feature of asthma and nonasthmatic
eosinophilic bronchitis. Siddiqui S, Sutcliffe A, Shikotra A, Woodman L, Doe C, McKenna S, Wardlaw A, Bradding P, Pavord I, Brightling C. J Allergy Clin Immunol. 2007 Oct;120(4):813-9. doi: 10.1016/j.jaci.2007.05.028. Epub 2007 Jul 5.
The airway smooth muscle CCR3/CCL11 axis is inhibited by
mast cells. Saunders R, Sutcliffe A, Woodman L, Kaur D, Siddiqui S, Okayama Y, Wardlaw A, Bradding P, Brightling C. Allergy. 2008 Sep;63(9):1148-55. doi: 10.1111/j. 1398-9995.2008.01684.x.
Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1. Woodman L, Siddiqui S, Cruse G, Sutcliffe A, Saunders R, Kaur D, Bradding P, Brightling C. J Immunol. 2008 Oct 1;181(7): 5001-7. doi: 10.4049/jimmunol.181.7.5001.
Airway smooth muscle proliferation and survival is not
modulated by mast cells. Kaur D, Hollins F, Saunders R, Woodman
L, Sutcliffe A, Cruse G, Bradding P, Brightling C. Clin Exp Allergy. 2010 Feb;40(2):279-88. doi: 10.1111/ j.1365-2222.2009.03423.x. Epub 2009 Dec 16.
Mast cell fibroblastoid differentiation mediated by airway
smooth muscle in asthma. Kaur D, Saunders R, Hollins F, Woodman L, Doe C, Siddiqui S, Bradding P, Brightling C. J Immunol. 2010 Nov 15;185(10):6105-14. doi: 10.4049/jimmunol.1000638. Epub 2010 Oct 15.
Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin. Kaur D, Doe C, Woodman L, Heidi Wan WY, Sutcliffe A, Hollins F, Brightling C. Chest. 2012 Jul;142(1):76-85. doi: 10.1378/chest.11-1782.
Primary human airway epithelial cell-dependent inhibition of
human lung mast cell degranulation. Martin N, Ruddick A, Arthur
GK, Wan H, Woodman L, Brightling CE, Jones DJ, Pavord ID, Bradding P. PLoS One. 2012;7(8):e43545. doi: 10.1371/journal.pone.0043545. Epub 2012 Aug 27.
Synthetic response of stimulated respiratory epithelium: modulation by prednisolone and iKK2 inhibition. Woodman LB, Wan WYH, Milone R, Grace K, Sousa A, Williamson R, Brightling CE. Chest. 2013 Jun;143(6):1656 1666. doi: 10.1378/chest.12-1187.
IL-33 drives airway hyper-responsiveness through IL-13- mediated mast cell: airway smooth muscle crosstalk. Kaur D, Gomez E, Doe C, Berair R, Woodman L, Saunders R, Hollins F, Rose FR, Amrani Y, May R, Kearley J, Humbles A, Cohen ES, Brightling CE. Allergy. 2015 May;70(5):556-67. doi: 10.1111/all.12593. Epub 2015 Mar 16.
NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma. Wan WY, Hollins F, Haste L, Woodman L, Hirst RA, Bolton S, Gomez E, Sutcliffe A, Desai D, Chachi L, Mistry V, Szyndralewiez C, Wardlaw A, Saunders R, O’Callaghan C, Andrew PW, Brightling CE. Chest. 2016 Jun;149(6):1445-59. doi: 10.1016/j.chest. 2016.01.024. Epub 2016 Feb 2.
Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma. Singh SR, Sullo N, Matteis M, Spaziano G, McDonald J, Saunders R, Woodman L, Urbanek K, De Angelis A, De Palma R, Berair R, Pancholi M, Mistry V, Rossi F, Guerrini R, Calò G, D’Agostino B, Brightling CE, Lambert DG. Br J Pharmacol. 2016 Apr;173(8):1286-301. doi: 10.1111/bph.13416. Epub 2016 Mar 6.